Abstract
Publisher Summary This chapter focuses on the neuroimmune amplification and inhibition of mucosal function. The mucosa of the mammalian gastrointestinal tract consists of an array of cell types, for example, enterocytes, fibroblasts, lymphocytes, mast cells, and other inflammatory cells and neurons, which when presented with an antigenic stimulus may interact to successfully remove the noxious agent. The small intestine has the ability to alternate from net absorption to net secretion, an important function in host defense that acts to maintain homeostasis. When this system fails, the result is chronic inflammation, pathophysiology, and disease. The studies presented in the chapter in rodent models demonstrate that mast cells are the focal effector cell type in intestinal hypersensitivity reactions. The presence of a functional enteric nervous system appears to be necessary for maximum responses to antigen to take place. This illustrates the role of neuroimmune interactions. Mediators and cytokines from other inflammatory cells or structural cells may further amplify the response.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
