Abstract
Computer modelling is a modern technique that helps research in medical applications to design and develop their devices. In this chapter, small molecule diffusion theories based on Fick’s law are introduced first. A simplified Fickian model is used to derive diffusion kinetic models with the aid of classical mathematics. Based on the outcomes of the kinetic models, Fickian and non-Fickian diffusion kinetics were discussed for biodegradable polymers. This is followed by computer modelling of the polymer degradation. It starts with introduction of degradation mechanism and then computer modelling. Basic computer modelling methodologies are discussed. The outcomes of the modelling with experimental results are discussed. These computing models can be used to predict biodegradation rate, molecular weight, oligomer diffusion, as well as mechanical properties of a bioresorbable polymer system.
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