Abstract
Studies of the relative effects of growth hormone ( GH ) and vitamin B-6 on the in vivo uptake of «-C-aminoisobutyric acid ( AIB ) in liver, diaphragm and heart of vitamin B-6-deficient rats were conducted. Generally, greater cellular uptake of AIB was observed in deficient than control rats. This increased uptake was particularly marked in liver. GH or vitamin B-6 injected with AIB 3 hours prior to sacrifice had little effect on uptake. In rats given AIB 24 hours prior to sacrifice, acute GH treatment (2 hours) resulted in stimulated uptake in deficient liver, diaphragm and heart and control liver, whereas control heart uptake was depressed. In contrast, chronic GH treatment of deficient rats depressed heart uptake and had little effect in liver and diaphragm, whereas vitamin B-6 administration depressed uptake in all three tissues. The results are compatible with reports of altered growth hormone metabolism in vitamin B-6-deficient rats. J. Nutr. 103: 1352-1358, 1973.
Published Version
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