Abstract
Age dependency of enzymes involved in the energy generating system was investigated in 600 g supernatants of quadriceps muscle from rats of different ages. (14-C) pyruvate oxidation rates (± ADP) increased a significantly from low early values in the neonatal period (321 ± 113 nmol/h/mg prot.) to nearly adult values at the end of the suckling period (859 ± 199 nmol/h/mg prot.) (p < 0.01). Pyruvate dehydrogenase complex (PDHC), citrate synthase and cytochrome c oxidase showed similar patterns of development. Immunoblot studies of PDHC indicated that E1α, the regulatory subunit of the multi-enzyme complex, is ihe most rapidly increasing protein with age. This study demonstrates a clear increase in mitochondrial oxidative capacity in rat muscle up until weaning which is in accordance with the known differententiation pattern of skeletal muscle fibers.
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