Abstract
Selenoproteins (eg glutathione peroxidases, thioredoxin redoxin reductases, some methionine sulfoxide reductases) play a key role in reducing oxidative stress. Diabetes is linked with impaired wound healing, and increased infection and tissue morbidity. Hypothesis: that a novel seleno-sugar (SeTal) with antioxidant activity would reduce oxidative damage, decrease chemotactic signals and inflammatory mediators, and improve wound healing in wildtype and diabetic mice. Methods Pairs of circular incision wounds on wildtype C57/BL6 and diabetic (db - /db - ) mice (n=12) were treated with SeTal (1 mM) or vehicle, topically for 10 days. Wound closure, vascular perfusion (Doppler imaging) and tissue histology were assessed. Results Wound closure in wildtype mice treated with SeTal was 2-fold greater than controls at day 4 (32% vs 17.5%, p Conclusions Enhanced wound healing occurs in the presence of the novel selenium compound. This enhancement was more marked in diabetic compared to wildtype mice. The decrease in monocyte chemotactic activity, IL-6 expression and improvements in tissue elasticity and tensile strength, suggest that this selenium compound may aid wound healing.
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