Abstract
It is not known whether 1) hypocalcemic (HC) IDM (Ca <7 mg/dl) have a deficiency in 1,25(OH)2D and 2) whether prospective control of diabetes during pregnancy affects the incidence of HC in IDM. 22 subjects were randomly assigned during the 1st trimester to strict vs. customary treatment groups. Serum 1,25(OH)2D (HPLC - protein binding assay) levels in IDM at birth were 29.5±2.4 (SEM) and increased to 60±7 at 24 hrs. (p<.0003) and to 95.6±15.5 pg/ml (p<.01) at 72 hrs. Maternal levels decreased from 49.6±5.7 pg/ml at birth (elevated vs. normal adults 29±1.2) to 29.1±3.9 pg/ml (p<.0005) at 72 hrs. At birth 25OHD (protein binding assay adults 11-69) values were normal in IDM 32±5.4 ng/ml and mother 40.1±3.5 and did not change postnatally. Customary treatment IDM had a significantly higher (5/11) incidence of hypocalcemia in the first 72 hrs. vs. 0/11 in the strict control group (X square 6.5, p<.01). Serum Ca of <8.0 mg/dl in mothers during the first 72 postnatal hrs. Were highly predictive of HC in IDM: of 9 mothers with Ca <8 mg/dl, 5 had HC-IDM vs. 0 HC-IDM in 13 mothers with Ca >8 mg/dl (X square 9.4, p<.002). 1,25(OH)2D and 25OHD levels were not different in HC-IDM vs. non HC-IDM. We conclude that 1) vitamin D metabolism is not deficient in hypocalcemic IDM and 2) diabetic control during pregnancy significantly affects the incidence of hypocalcemia in infants.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
