1416 ARE WE EVALUATING PROPERLY THE RENAL FUNCTION WITH THE MODIFICATION OF DIET IN RENAL DISEASE (MDRD) IN PATIENTS WITH ORTHOTOPIC ILEAL NEOBLADDER?

Abstract

You have accessJournal of UrologyUrinary Diversion: Bladder Reconstruction, Augmentation, Substitution, Diversion (II)1 Apr 20131416 ARE WE EVALUATING PROPERLY THE RENAL FUNCTION WITH THE MODIFICATION OF DIET IN RENAL DISEASE (MDRD) IN PATIENTS WITH ORTHOTOPIC ILEAL NEOBLADDER? Mathieu Rouanne, Yann Neuzillet, Dominique Eladari, Thierry Lebret, and Henry Botto Mathieu RouanneMathieu Rouanne Suresnes, France More articles by this author , Yann NeuzilletYann Neuzillet Suresnes, France More articles by this author , Dominique EladariDominique Eladari Paris, France More articles by this author , Thierry LebretThierry Lebret Suresnes, France More articles by this author , and Henry BottoHenry Botto Suresnes, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2770AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Few studies assessing prospectively the renal function changes after orthotopic ileal bladder substitution are available.The aim was to evaluate the accuracy of Modification of Diet in Renal Disease (MDRD) formulae as a substitute for the gold standard measure of glomerular filtration rate (GFR) using chromium 51 EDTA. METHODS Seventeen consecutive patients underwent radical cystectomy (RC) from July 2011 to December 2011 for muscle-invasive bladder cancer were included in this prospective protocol. Exclusion criteria were chronic kidney disease (CKD) and neoadjuvant chemotherapy. Bias and precision of estimated GFR (eGFR) were compared with isotopic GFR (iGFR). Chromium-51 ethylenediamine tetra-acetic acid (51 Cr-EDTA) was used to measure the glomerular filtration rate of both kidneys. 51Cr-EDTA GFR was performed preoperatively and 6 mo postoperatively. In addition, technetiumTc99m-diethylenetriaminepentaaceticacid (Tc99m-DTPA) renal scintigraphy was used to determine the glomerular filtration rate (GFR) of each kidney individually. RESULTS Mean preoperative GFR values were 84 ml/min per 1.73 m2 (range to 61-116) and 75 ml/min per 1.73 m2 (range to 60-117) using eGFR and 51 Cr-EDTA GFR respectively. At 6 mo, the mean GFR values were 77 ml/min per 1.73 m2 (range to 60-117) and 68 ml/min per 1.73 m2 (range to 60-102) using eGFR and iGFR respectively. At 6 mo, the difference between 51 Cr-EDTA GFR and eGFR was statistically different (p = 0.035). In addition, 51 Cr-EDTA GFR values were statistically different between preoperative time and at 6 mo ((p=0.025) whereas no statistical significant difference was found using eGFR (p > 0.05). CONCLUSIONS There is poor correlation between eGFR and 51Cr-EDTA GFR in patients with ileal neobladder reconstruction. eGFR should be used with caution as a surrogate marker for isotope GFR in these patients. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byRouanne M, Lebret T and Courbebaisse M (2018) Re: Long-Term Renal Function Outcomes after Radical CystectomyJournal of Urology, VOL. 193, NO. 3, (1066-1067), Online publication date: 1-Mar-2015. Volume 189Issue 4SApril 2013Page: e580 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mathieu Rouanne Suresnes, France More articles by this author Yann Neuzillet Suresnes, France More articles by this author Dominique Eladari Paris, France More articles by this author Thierry Lebret Suresnes, France More articles by this author Henry Botto Suresnes, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...