140 INCIDENCE AND RISK FACTORS FOR CONTRAST INDUCED NEPHROPATHY IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION AT A TERTIARY CENTRE

Abstract

Category: Research in AKI (Basic, translational, clinical including clinical trials) Presenter: Dr AZRINI ABDUL AZIZ Keywords: contrast induced nephropathy, percutaneous coronary intervention Contrast induced nephropathy (CIN) following percutaneous coronary intervention (PCI) is associated with adverse outcomes. Risk factors to predict CIN are chronic renal failure, diabetes, congestive cardiac failure and contrast volume. The aim is to determine the incidence of CIN after PCI in a tertiary centre and identify risk factors for patients to develop to CIN for preventive measures. All patients who underwent PCI between January - June 2016 were screened. Patients with rise in creatinine by 25% or 44mmol/L (0.5mg/dL) from baseline within 48 to 72hours after contrast administration in the absence of other explanation were selected. A total of 524 patients who underwent PCI between January to June 2016 were included in the study. 32 (6.1%) patients develop CIN with 4 patients (12.5%) requiring renal replacement therapy. 19 out of 32 patients (59.4%) were diabetic, and 17 (53.1%) had eGFR less than 60. The mean contrast volume administered was 169.63ml for the CIN group and 165.11ml for the non CIN group with p=0.851. The mean age for the CIN group was 60.91 and 55.72 for the non CIN group with p=0.037. The overall incidence of CIN post PCI is low at 6.1%, however 12.5% required renal replacement therapy. This could be attributed to lower contrast volume and preventive measures with hydration and use of N-acetylcysteine. Predisposing risk factors to develop CIN are diabetics, those with eGFR less than 60ml/min and elderly patients. Routine blood monitoring and follow up is recommended especially in high risk group.