Abstract
The nuclear lamina is an essential component of metazoan cells. Not only does the nuclear lamina provide structural support and integrity to the nucleus, it is also involved in most nuclear activities, providing an integrated interface between the cytoskeleton and the nucleus. The nuclear lamina has roles in nuclear integrity, mitosis, mechano-sensation, DNA replication, signaling, regulation of transcription, and genome organization. In this chapter, we discuss the nuclear lamins and their dynamic interactions with both cytoskeletal and nuclear components and focus on the emerging role of the nuclear lamina as a key regulator of genome organization.
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