Abstract
Objective: The aim of this study was to detect the pseudonormalization of left ventricular diastolic dysfunction in patients with non-insulin-dependent diabetes mellitus (NIDDM). Methods: We studied 103 patients with NIDDM (with age 57±8.2 years, 34 men) and no clinical evidence for ischemic heart disease (Group 1) and 103 subjects without diabetes as a control group (Group 2) matched by age and sex. Twodimensional, M-mode and pulsed-Doppler echocardiography were performed to assess LV systolic and diastolic function. Color M-mode echocardiography was performed in patients with normal pulsed-Doppler findings. To exclude the presence of coronary artery disease, exercise test with treadmill was performed. Results: The E/A ratio of mitral inflow registered by pulsed-Doppler indices had significant differences between Group 1 and Group 2 patients (0.83±0.3 vs 1.16±0.38, p 1 resulted with velocity propagation (Vp) <55cm/s. This was a significant difference between groups (p<0.01). Conclusions: Left ventricular diastolic function is reduced in NIDDM patients with no symptoms of cardiovascular disease and with negative exercise test. The prevalence of pseudonormalization was significantly higher in NIDDM patients than in control subjects.
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