Abstract
Several empirical studies have reported high prevalence of atopic disordersin Woplewithdepression.In, addition,hyperrqxmsivenessto choiinergicagonists has been found both in people diagnosedwith allergicasthmaand in peoplediagnosedwithdepression.In this study, cholinergic hyperresponsiveFlinders Sensitive Line (FSL) rata (an animal model of depression),and their control counterpartsFlinders Resistant Line (FRL) rats were comparedfor their susceptibilityto experimentalasthma.Airwayresponsivenesswas assessedin spontaneouslybreathing,unrestrainedanimalsby meansof wholebodyplethysmography.Increasedairwayresponsivenessof FSLrats was evidenced as a morepronouncedincreasein Perdrvalue(enhancedpause,an index of bronchoconstriction) acrossdifferentconcentrationsof methacholine (F.,ll, = 10.27;p< O.001). In subsequentexperirnen%FSLandFRLrats weresensitizedto ovalbuminandchallengedwithnebulizedantigen.The data indicate that geneticallytransmittedcholinergichyperresponsiveness of the FSL rat is paralleled by its increased susceptibilityto allergen-inducedbronchoconstriction(Fl,3.r= 54.86; p<O.~1) and inflammationof the airways (FI,34= 15.65;p< O.001).‘flus study provides further evidence for a common cholinergicmechanismin susceptibilityto bothasthmaand depression.
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