Abstract
The title compound, C32H50O10, prepared from a mixture of α- and β-dihydroartemisinin, has two β-arteether moieties linked via an –OCH2CH2O– bridge, so that the molecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an –OCH2 group, which is only one-half of the molecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations.
Highlights
The title compound, C32H50O10, prepared from a mixture of and -dihydroartemisinin, has two -arteether moieties linked via an –OCH2CH2O– bridge, so that the molecule is symmetric about the bridge
We report here the crystal structure of a diol dimer of dihydroartemisinin, the title compound, which is a diol dimer of dihydroartemisinin with a unique 1,2,4-trioxane peroxy bridge
R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger
Summary
R factor = 0.042; wR factor = 0.129; data-to-parameter ratio = 8.3. The title compound, C32H50O10, prepared from a mixture of and -dihydroartemisinin, has two -arteether moieties linked via an –OCH2CH2O– bridge, so that the molecule is symmetric about the bridge. Each asymmetric unit contains a -arteether moiety and an –OCH2 group, which is only one-half of the molecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diolbridged dimer. The rings exhibit chair and twist-boat conformations
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