1282 RISK-ADAPTED SCREENING PERFORMED WITH THE INTERNET TOOL RISKCHECK BLADDER CANCER© (RCBC) WAS EVALUATED BY THE UROLOGICAL HEALTH SERVICE RESEARCH FOUNDATION IQUO-GERMANY

Abstract

You have accessJournal of UrologyBladder Cancer: Detection & Screening1 Apr 20131282 RISK-ADAPTED SCREENING PERFORMED WITH THE INTERNET TOOL RISKCHECK BLADDER CANCER© (RCBC) WAS EVALUATED BY THE UROLOGICAL HEALTH SERVICE RESEARCH FOUNDATION IQUO-GERMANY Gerson Lüdecke, Götz Geiges, and Frank König Gerson LüdeckeGerson Lüdecke Giessen, Germany More articles by this author , Götz GeigesGötz Geiges Berlin, Germany More articles by this author , and Frank KönigFrank König Berlin, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2636AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The open-access questionnaire RCBC was proven in daily routine work from German urologists organized in the health services research foundation IQUO on asymptomatic patients. In consequence we could characterize our patient population in respect to BC risk exposure and the presence of BC in this risk population. METHODS The open-access RCBC questionnaire was used in urological offices to check asymptomatic patients for their BC risk exposure. All people with intermediate and high risk were checked for tumor presence by urine diagnostics, optional by ultrasound and in case of suspect results controlled by cystoscopy. IBM-SPSS 20 was used for statistical analysis; incidence, distribution and correlation between risk stratification and tumor detection. The effectiveness was proven by classification tree analysis and cross-table analysis with Chi-square test. Significance was defined with p < 0.05. RESULTS Out of 303 checked asymptomatic persons 274 (90.4%) were negative for tumor and 29 (9.6%) had a detectable tumor. In the group of NED 176 (68.1%) persons were classified as low risk, and 98 (16.2%) with tumor risk. Out of the 29 detected tumors 20 were at intermediate or high risk (68.9%). This resulted in an over all detection rate of 6.6% and focused on the risk population of 16.9%. The association of tumor presence and increased risk identified by RCBC assessment was significant (p < 0.01). This described a sensitivity of 69.0%, a specificity of 64.2%, NPV of 95.1%, PPV of 16.9%, false positive cases of 35.8%, false negative cases of 31.0% and a accuracy of 64.7%. Compared to the documented incidence rates for Europe and the industrialized countries (35/100,000) this is an increase in effectiveness of 188.6 in the screened study population and 482.8 in relation to the risk population alone. CONCLUSIONS Risk-adapted screening in bladder cancer delivers a reasonable approach to diagnose bladder cancer before emerging symptoms. Preventive medical care becomes effective because RCBC is able to condense the screened population with focusing investigations on people living under risk. With a NPV of 95.1% unnecessary investigations can be minimized effectively. In consequence the assessment is work effective and aim achieving. The quote of over locked tumors (2.9%) was low and all NMIBC with low-risk grading. The questionnaire RCBC integrates evidence based bladder cancer inductors, is easy in use and as an open-access tool available in 10 languages via internet. www.riskcheck-bladder-cancer.info. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e524-e525 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gerson Lüdecke Giessen, Germany More articles by this author Götz Geiges Berlin, Germany More articles by this author Frank König Berlin, Germany More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...