MP72-10 THE OUTCOME OF PATIENTS WITH HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER IN SWEDEN

Abstract

You have accessJournal of UrologyBladder Cancer: Non-invasive III (MP72)1 Apr 2020MP72-10 THE OUTCOME OF PATIENTS WITH HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER IN SWEDEN Eugen Wang*, Ulf Larsson, Truls Gårdmark, and Per-Uno Malmström Eugen Wang*Eugen Wang* More articles by this author , Ulf LarssonUlf Larsson More articles by this author , Truls GårdmarkTruls Gårdmark More articles by this author , and Per-Uno MalmströmPer-Uno Malmström More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000952.010AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: At the time of bladder cancer detection, about 2/3 are non-muscle invasive bladder cancer (NMIBC). The high-risk NMIBC tumor types (TaG3, T1G2,T1G3 or/and Tis) present an increased risk of progression to deep-growing cancer and metastasis. Our aim was to identify this group of patients in the Bladder Cancer Data Base Sweden (BladderBaSe) and analyze the cancer specific survival after different managements. METHODS: BladderBaSe was created in 2015. This database links information from the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, with a number of national health care and demographic registers through the use of the personal identification numbers. The national register has detailed data on 97% of the bladder cancer cases diagnosed in Sweden. In 1997-2014 in Sweden, a total of 26808 patients were diangosed with NMIBC, of whom 10209 were high-risk cancer with median age 71 and 80 % male. 5660 patients were treated with TURBT only, 3862 had inital Bacillus Calmette-Guérin (BCG). Radical cystectomy was performed in 687 patients initially while 399 had delayed cystectomy after BCG. RESULTS: Characteristics of patients with high risk NMIBC is shown in table 1. During the follow-up 5 years, the cancer specific survival chance was higher for the BCG group (85 %) than it was for the initial radical cystectomy (75 %) or TURBT only group (65 %). (Fig.1). In a Cox proportional hazards model younger patients, lower cancer stage, initial treatment with BCG and treatment in high volume university hospital was associated with better survival. CONCLUSIONS: Initial BCG installation with or without delayed cystectomy improved cancer specific survival more than initial cystectomy in high-grade T1 bladder cancer in this population registry. However selection criteria could be a cause for confounding and will be further studied. Source of Funding: Schmekel fund in Urological research © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1077-e1077 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eugen Wang* More articles by this author Ulf Larsson More articles by this author Truls Gårdmark More articles by this author Per-Uno Malmström More articles by this author Expand All Advertisement PDF downloadLoading ...