Abstract
Background: Kirsten Rat Sarcoma (KRAS) viral oncogene is the most common oncogenic driver in non-small cell lung cancer (NSCLC), altered in around 25–30% adenocarcinomas and present in both localized and advanced disease. Within KRAS, G12C, G12 V and G12A mutations are generally related with the smoking habit. Despite being highly prevalent aberrations, the predictive and prognostic roles of these molecular alterations still are investigational in NSCLC patients treated with immunotherapy (IT).
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