Abstract
The aim of these present study was to evaluate maternal levels of S100B (a neural protein found in high concentrations in biological fluids after cell injury in the nervous system), in pregnancies complicated by intrauterine growth retardation (IUGR) and to correlate after their measurements with postnatal intraventricular hemorrhage (IVH) occurrence. A case-control study in pregnant women complicated by IUGR(n= 106) of whom a subgroup (n=26) developed postnatal IVH, and a group of normal pregnancies (n=212) matched for gestational age served as control. Ultrasound scanning, Doppler velocimetry patterns (in the utero-placental and in the middle cerebral artery vessels), and maternal blood samples were collected before birth in all women with IUGR. After birth routine laboratory parameters, cerebral ultrasound patterns and neurological examination were recorded in IUGR and control newborns.Maternal S100B levels were significantly (P<0.001) higher in IUGR pregnancies complicated by postnatal IVH, than in those who did not and in controls. At a cut-off of 0.72 mg/L S100B achieved a sensitivity of 99.3% (C.I.95%: From 86.7 to 100) and a specificity of 98.2% (C.I.95%: From 94.3 to 99.8) as a single marker for prediction of IVH (area under the ROC curve: 0.991). The probability of IVH was 8.17% in the whole study population, 93% (C.I.95%: 83.6–100%) when S100B levels were found above the thresholds defined by the ROC curve analysis, and 0% (C.I.95%: 0–2.5%) if they were found unaltered. Maternal S100B assessment may represent an useful tool for the early suspect of postnatal IVH.
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