Abstract
Growing evidence suggests an increased risk of incident chronic diseases such as cardiovascular diseases (CVDs) after COVID-19. We evaluated the risk of CVDs >30 days after a COVID-19 diagnosis and compared it to a contemporaneous control group without a COVID-19 diagnosis. We included adults ≥20 years with a COVID-19 diagnosis from March 1, 2020 through December 1, 2021 from the IQVIA insurance claims database. The contemporaneous control group comprised adults with ≥1 healthcare encounter and without diagnoses for COVID-19 or other acute respiratory infections. Control group index dates were randomly selected to match the distribution of COVID-19 diagnosis dates. All diagnoses were ascertained from ICD-10 codes. Individuals with diagnostic codes of CVDs within 2 years prior to the index date were excluded. We used Cox regression models (adjusted for age, sex, health insurance type, U.S. Census division, Charlson comorbidity score) to assess the risk of incident CVDs, stratifying by diabetes status. The analytic sample included 13,078,827 adults (mean age 49.4 years [SD: 15.7], 50.2% female, and mean follow-up 8.5 months [SD: 5.8]). Among patients with and without diabetes, COVID-19 diagnosis was significantly associated with increased risk of each CVD outcome (See Figure). Regardless of diabetes status, monitoring for incident CVD may be pertinent beyond the first 30 days of COVID-19. Disclosure A.Koyama: None. M.E.Pavkov: None. G.Imperatore: None. D.B.Rolka: None. E.A.Lundeen: None. R.Rutkowski: None. S.Jackson: None. S.He: None. E.V.Kuklina: None. S.Park: None.
Published Version
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