123 (PB-036) Poster - Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancer cases excludes additional high-impact susceptibility genes

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Background: To better understand the unexplained ∼60% of the genomic architecture of breast cancer susceptibility, we undertook germline whole exome sequencing (WES) of 2,135 BRCA-negative female breast cancer cases. Our series was highly enriched for early-onset, bilateral, family history of disease and concomitant ovarian cancer, substantially boosting power for discovery.