1219-P: HDL Particle Concentration (HDL-P) and Cholesterol Efflux Capacity (CEC) Trajectories Relative to Age at Menopause in Women with Type 1 Diabetes

Abstract

A previous study in the general population reported adverse changes in the concentration of HDL-P and CEC during the menopausal transition. Similar data do not exist in women with T1D. Moreover, whether changes in HDL metrics over time at a similar age also occur among men, reflecting aging processes, is not well established. We thus quantified HDL-P (calibrated differential ion mobility analysis), total and ABCA1-specific CEC in individuals with T1D and samples available at baseline (or earliest available) and the 25-year follow-up visit of the EDC study (n=155; mean baseline age 27; T1D duration 19 years). Each female participant was age and duration matched (at the time of menopause) to a male participant. Mixed models were constructed to assess the longitudinal trends in HDL-C, HDL subfractions and CEC. Plots were created depicting trajectories of HDL metrics relative to the time of the final menstrual period in women. As shown in the Figure, HDL-C and HDL-P concentrations increased significantly over time in both sexes. In addition, both CEC measures as well as CEC per HDL-P decreased over time in both men and women. Our findings in T1D point to similar trajectories of HDL metrics in men and women (increasing HDL-C and HDL-P but decreasing CEC per HDL-P) suggesting that these changes partially relate to aging and not exclusively to menopause. Disclosure J.Ju: None. R.G.Miller: None. T.J.Orchard: None. T.Costacou: None. Funding National Institutes of Health (R01HL130153, R01DK034818)