Abstract
Despite the high potential of metabolomics, its applications for nutrition are still in their infancy. Metabolomics is currently challenged by the use of large data sets to identify metabolites and to interpret their biological functions. The combined use of isotopic labelling and metabolomics seems to be a promising future strategy for the quantification of metabolites in complex matrices such as biofluids and tissues. In addition, the emerging field of in situ metabolomics can provide detailed spatial distributions of metabolites. All these developments offer metabolomics the potential to couple the quantification of metabolites with a spatiotemporal dimension, giving it greater relevance for the biological interpretation of data.
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