Abstract
Extracellular matrix (ECM) is one of the key primary and essential substances that are produced by the natural tissues through a complex mechanism. ECM by its complex nanoscale composite nature provides a home for hundreds of chemical reactions and molecular and cellular interactions that ultimately maintain and regulate the natural tissue’s viability and functions. Therefore, a basic understanding of the physiological tissues and the cellular and molecular interactions are of great importance. In this context, the study of ECM would help researchers to better design, optimize, and apply different biomaterials in the field of therapeutic or regenerative medicine. This chapter provides a comprehensive summary of basic studies on ECM, shedding light on several relevant topics that are currently the focus of many research studies.
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