117 Prenatal diagnosis of osteogenesis imperfecta type 3 and 4: A case report

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Introduction: Osteogenesis imperfecta (OI) is a rare, inherited connective tissue disorder with result in severe bone fragility and multiple fractures. Mostly, a mutation in one of the two genes involved in the production of collagen type 1 (COL1A1 and COL1A2) is responsible for OI. Types 1 and 4 are usually diagnosed with postpartum fractures. Types 3 can be detected in late second or early third trimester, due to bowing of long bones and fractures. Methods: A 28-year-old, 18 weeks of gestation, gravida 2, para 1, woman was referred to our center.