Abstract
Liver injury can cause liver failure and mortality, which have attracted a considerable concern in modern medicine. Peroxisomes are known to decompose lipid and produce lipid radicals which are involved in liver injury. Meantime, these organelles also generate reactive oxygen and nitrogen specie. To date, the role of lipid radicals in peroxisome in the process of liver injury has been researched extensively, but a rare effort is dedicated to study the effects of reactive oxygens and reactive nitrogen in peroxisomes on the occurrence and development of liver injury. Recently, a lot of works have reported that the high level of peroxynitrite (ONOO-) are observed in liver injury. So, we developed a new peroxisome-targeted and two-photon fluorescent probe for detecting ONOO-. The probe, named PX-1, was successfully applied to imaging ONOO- in vivo. And the experimental results showed that PX-1 can real-time monitor the level of ONOO- in peroxisomes with high specificity and sensitivity. Moreover, ONOO- was found to be elevated in mice with carbon tetrachloride-induced liver injury. We believe that PX-1 can be used as a potentially useful tool to study the mechanism of liver injury related to ONOO- in peroxisomes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
