Abstract
Background To evaluate the acute effect of different fractionation schedule (hypofractionation and convention fraction) of radiation therapy on lung in patient of carcinoma breast. Methods This randomised prospective multicentric study was conducted with a 130 breast cancer patients who are all candidate for the adjuvant radiation therapy. Spirometry based PFT were done before radiation therapy as base line, at 1 month after RT and once in every 3 months.out of 130 patients, 70 were treated with hypofractionation (40Gy in 15#) and other 60 were treated with conventional fractionation schedule (50Gy in 25#) to chest wall and SCF( +/-). All patients were treatedwith3DCRTasperthedepartmentalprotocoloftheinstitutes.Therelative changes in the PFT parameters were correlated with irradiated lung dose by using dose volumehistogram(DVH).Relevantstatisticaltestswereusedforanalysis. Results: Conclusions There will be more acute lung reaction (reflected on reduction on PT parameters) in conventional fractionation arm, patient with age more than 60 and ipsilaterallungvolumeoflessthan950cc.Thusselectionoffpatientstillneedtobe caution on fractionation schedule. Further follow up to know weather the acute effect will reflect on late radiation effect. Legal entity responsible for the study N/A Funding N/A Disclosure All authors have declared no conflicts ofinterest.
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