1125 DEVELOPMENTAL TIME COURSE OF VENO-OCCLUSIVE DYSFUNCTION AFTER BILATERAL CAVERNOSAL NERVE RESECTION DETERMINED BY TELEMETRY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 20111125 DEVELOPMENTAL TIME COURSE OF VENO-OCCLUSIVE DYSFUNCTION AFTER BILATERAL CAVERNOSAL NERVE RESECTION DETERMINED BY TELEMETRY Keisha K. King, Ramon Martinez, Istvan Kovanecz, Leah A. Garcia, Sateysh Sinha, Jorge N. Artaza, and Monica G. Ferrini Keisha K. KingKeisha K. King Los Angeles, CA More articles by this author , Ramon MartinezRamon Martinez Los Angeles, CA More articles by this author , Istvan KovaneczIstvan Kovanecz Torrance, CA More articles by this author , Leah A. GarciaLeah A. Garcia Los Angeles, CA More articles by this author , Sateysh SinhaSateysh Sinha Los Angeles, CA More articles by this author , Jorge N. ArtazaJorge N. Artaza Los Angeles, CA More articles by this author , and Monica G. FerriniMonica G. Ferrini Los Angeles, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.722AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Cavernosal Veno-occlusive dysfunction (CVOD) which normally occurs when there is both a loss of smooth muscle cells together with an increase in fibrosis within the corpora cavernosa, can be experimentally induced by an injury to the cavernosal nerves. We examined the use of telemetric monitoring of the intracavernosal pressure as a new reliable and non invasive method to assess CVOD following bilateral cavernosal nerve resection (BCNR) in the rat. METHODS Two month-old male Fisher 344 rats (n=8) were implanted with PhysioTel PA-C40 transmitters to monitor intracavernosal pressure. 7 days after implantation, penile intracavernosal pressure (ICP) measurements were collected by telemetry over three 12 hour periods and averaged to determine basal pressures for each animal as well as the average duration and peak heights for spontaneous erections. Animals were also injected subcutaneously with apomorphine, (60μm/kg B.W.) or intracavernosally with papaverine (15 mg/ml) After determining the ICP benchmark, Animals were then subjected to BCNR and ICPs were recorded over 12 hour during 2 month period. RESULTS In control animals, recording of the basal pressure were 28.1±2.9 mmHg. The number of spontaneous erectile events in 12 hour period were 19.5±2.74. The erectile event lasted 21± 1.3 sec and the ICP for full erections were 152.71±17.1 mmHg. Apomorphine injection induce an ICP of more than 200 mmHg and intracavernosal injection of papaverine induced an increase of the ICP up to 300 mmHg. BCNR induce a decrease in the number of spontaneous erection starting at 7 days after the surgery and reaching the maximum at 30 days with a decrease of 80% in the number of spontaneous. The basal pressure dropped to 15 mmHg and the maximum icp for erection reached 80 mmHg. CONCLUSIONS BCNR induces changes in the intracavernosal pressure indicating that resulting CVOD reaches the maximum at 30 days after surgery. Telemetry is a reliable method to measure erectile function and can be used to determine the changes in the intracavernosal pressure after nerve damage at different time point on the same specimen providing more consistent physiological and behavioral data. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e452 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Keisha K. King Los Angeles, CA More articles by this author Ramon Martinez Los Angeles, CA More articles by this author Istvan Kovanecz Torrance, CA More articles by this author Leah A. Garcia Los Angeles, CA More articles by this author Sateysh Sinha Los Angeles, CA More articles by this author Jorge N. Artaza Los Angeles, CA More articles by this author Monica G. Ferrini Los Angeles, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...