1097 - Extranodal Non-Hodgkin Lymphomas in a Northern Portugal Institution - 2006/2010

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ABSTRACT Introduction Non Hodgkin lymphomas (NHL) can arise in nodal or extranodal lymphoid tissue. In about 20% of cases the initial presentation affects the extranodal sites, which characterize the primary extranodal NHL (PENL). Objectives Analyze the clinical and pathological characteristics of patients with PENL and evaluate prognostic factors. Material and methods Retrospective study of 66 patients diagnosed with PENL in an institution, between January 2006 and December 2010, and clinical-pathological data collection. Results The median age was 63 years (17-87), 52.3% were women and 17% had ECOG performance status greater than two. The most frequent location was the stomach (32.3%) followed by skin and subcutaneous tissue (23.1%). Seventy two percent were high grade lymphomas and 17% had T phenotype. The most common histologic type was diffuse large B cells NHL (DLCBL) (55.4%). In 3 (4.6%) cases there was extranodal secondary attainment. 76.9% of patients had stage I or II at diagnosis, 29.2% had B symptoms and 23% had increased lactate dehydrogenase (LDH). The albumin was decreased in 7,7% of the cases and the β2 microglobulin levels were increased in 12,3% of patients. Sixty-three percent were in the category of low-risk IPI. Seventy seven percent of patients underwent chemotherapy, 4.6% primary radiotherapy (RT) and 28% adjuvant radiotherapy. Seventy two percent of patients had complete remission and 23,1% were submitted to a second line treatment. In a median follow-up of 31 months, 13.8% relapsed. The estimated survival at 50 months was 79%. The high levels of LDH and β2 microglobulin, low albumin, high IPI and ECOG and extraganglionar secondary involvement constituted factors of poor prognosis. Conclusion This study showed a high prevalence of PENL of gastric and cutaneous location and of histologic subtype DLCBL. Most patients presented in early stages and with low IPI prognosis index. The response to primary treatment and the overall survival were high. We identify clinical and biological factors with prognostic value in univariable analysis. Disclosure All authors have declared no conflicts of interest.