1060 Does a second-degree relative with history of pre-eclampsia increase the risk of pre-eclampsia?

Abstract

A 1st degree relative with a history of pre-eclampsia (PE) is a well-known risk factor for PE. However, the risk of a more distant family member with a history of PE is not well defined. We hypothesized that a 2nd degree relative with a history of PE may be associated with development of PE. This was a retrospective cohort study of a prospectively collected perinatal database from a large academic medical center from 2011-2020. Under consent, subjects were queried in their native language as to both self and familial history, inclusive of the common obstetrical disorders. Maternal demographics and obstetrical outcomes were compared between pregnancies with and without a maternal family history of PE. Family members were classified as 1st degree (maternal sister) and 2nd degree (maternal grandmother or aunt). Logistic regression was used to evaluate the association of family history with development of PE. 1948 pregnancies had detailed family history information available. 105 (5.4%) of pregnancies had a family history of PE: 57 patients had a sister and 51 had a maternal aunt or grandmother with history of PE. Patients with a family history of PE had a higher mean BMI (29.0 vs. 28.3 kg/m2, p<.001) and chronic hypertension (20% vs 11.7%, p=0.011). On univariate logistic regression (Table 1), any family history of PE was associated with increased odds of developing PE or a hypertensive disorder of pregnancy. However, none of these findings remained significant with adjustment for BMI and hypertension. A 2nd degree relative with a history of PE was not associated with developing PE in our study. Having any family history of PE and having a sister with a history of PE were both associated with PE on univariate analysis but were not significant after adjustment. The study power was limited as only 105 patients with any family history of PE. Future work should be directed at a larger population to evaluate the risk more conclusively, and the current novel findings would support such efforts.