#1051 Association between anemia/iron deficiency and health-related quality of life in patients with advanced CKD: the Reach-J CKD cohort study

Abstract

Abstract Background and Aims Low Hb and low TSAT levels are associated with worse health-related quality of life (HRQOL) in patients from Brazil, France and USA in the CKD outcomes and Practice Patterns Study (CKDopps). However, there is little evidence for those in Asian countries. We aimed to evaluate the association between anemia/iron deficiency and HRQOL in Japan. Method We conducted a nationwide cohort study of Japanese patients with advanced CKD. We recruited 2249 patients with stage G3b-5 CKD receiving nephrologist care from 31 representative facilities throughout Japan, randomly selected with stratification by region and facility size, aligned with the CKDopps. The association between Hb and TSAT levels at enrolment and HRQOL derived from KDQOL-36 was evaluated. Results Mean age was 69.1 ± 12.6 years; 35.2% were female; mean body mass index was 23.6 ± 4.8 kg/m, mean eGFR was 23.2 ± 10.5 mL/min/1.73 m2. Mean Hb was 11.7 g/dL, mean TSAT was 31.4% and ferritin was 147.4 ng/mL. The mean physical component summary (PCS) scores, mental component summary (MCS) scores and scores on the three KDQOL subscales were worse with Hb <10, compared to ≥10 g/dL. Few differences in PCS and MCS scores were seen between the TSAT levels. Conclusion In Japanese patients with CKD, HRQOL was worse with Hb <10 g/dL and not associated with TSAT levels. These data will provide important information for international comparisons and the clinical practice of Asian patients with CKD.