Abstract
Infants of diabetic mothers have an increased incidence of thrombosis. In an attempt to evaluate the role of the platelet in the etiology of this thrombotic tendency, platelet rich plasma (PRP) from 15 control maternal-neonatal pairs was compared to PRP from 6 pairs in whom maternal diabetes mellitus was present. Platelet Malonyldialdehyde (MDA) formation (n moles per 109 platelets) in the presence of N-ethyl maleimide (NEM) or thrombin was measured as an indicator of platelet prostaglandin synthesis. Control maternal MDA values in the presence of NEM or thrombin were 3.23±0.31 (1SD) and 1.30±0.17 respectively, with control cord blood values being 2.46±0.61 and 0.90±0.19. There was a significant increase in platelet MDA to 3.74±0.49 (NEM) and 1.51±0.35 (thrombin) in the diabetic mothers. This finding was associated with platelet hyperaggregability in 3/6. Platelet MDA formation was also significantly increased in the infants of these diabetic mothers to 3.66±0.53 (NEM). Platelet hyperaggregability was present in 3/6 infants and was absent in all 15 control neonates. Platelet sizing did not differ significantly between the control or patient groups. Platelet prostaglandin synthesis appears increased both in the diabetic mother and her infant. The observed platelet hyperaggregability and increased Prostaglandin synthesis may contribute to the thrombotic tendency in the infant of the diabetic mother.
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