Abstract
Preeclampsia is a complex syndrome with variable phenotypes that suggest differing underlying pathogenic pathways. Definition of phenotypes and pathways demands very large datasets achieved by combining data from multiple studies. This ideally requires that the data are harmonized before collection and prior to merging. To this end, we have presented a strategy (1) of standardized data and biosample collection. To facilitate its adoption CoLab proposes that a standard database is created to be used online by interested investigators. The database will collect minimal and optimal datasets as previously outlined (1), the latter being an extension of the former. It is designed for online data acquisition and storage but will be available as a standalone system. It will allow for site-specific add-ons to address local priorities and could also serve as the template for study of other adverse pregnancy outcomes and for clinical studies. The online database will be available free of charge to low and middle income countries with a minimal monthly maintenance charge, applicable to high income countries. Acquisition of data in a standardized format across the globe will allow data to be pooled, achieving sufficient statistical power to discriminate sub-types of preeclampsia. These data could then be utilized to analyze underlying pathophysiology and to define phenotype outcomes and specific therapies. 1. Myatt L, Redman CW, Staff AC, Hansson S, Wilson ML, Laivuori H, Poston L, Roberts JM; for the Global Pregnancy CoLaboratory (COLAB). Strategy for Standardization of Preeclampsia Research Study Design. Hypertension. 2014;63:1293-301. L. Myatt: None. C.W. Redman: None.
Published Version
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