1024 EXERCISE AS A RADIOPROTECTOR OF ERECTILE FUNCTION AFTER PROSTATE RADIOTHERAPY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research (II)1 Apr 20131024 EXERCISE AS A RADIOPROTECTOR OF ERECTILE FUNCTION AFTER PROSTATE RADIOTHERAPY Mitchell Bassett, Xiaochun Lu, Hui Yan, Yingchun Zhou, Andrew Zodda, Jason Allen, Lee Jones, and Bridget Koontz Mitchell BassettMitchell Bassett Durham, NC More articles by this author , Xiaochun LuXiaochun Lu Durham, NC More articles by this author , Hui YanHui Yan Durham, NC More articles by this author , Yingchun ZhouYingchun Zhou Durham, NC More articles by this author , Andrew ZoddaAndrew Zodda Durham, NC More articles by this author , Jason AllenJason Allen Durham, NC More articles by this author , Lee JonesLee Jones Durham, NC More articles by this author , and Bridget KoontzBridget Koontz Durham, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.609AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Radiation causes normal tissue injury through hypoxia, oxidative stress, and vascular damage. Exercise is known to increase nitric oxide (NO) production and systemic vasodilation, improve tissue oxygenation, and increase free radical scavenging. Epidemiological studies suggest exercise may reduce likelihood of erectile dysfunction. Therefore we performed a four arm preclinical study evaluating the ability of exercise to prevent radiation-induced ED. METHODS 60 young adult male Sprague Dawley rats were divided into 1) control, 2) 14 Gy prostate irradiation, 3) exercise (1 hour per day 5 days per week on motorized running wheel at 6 m/min), or 4) RT + exercise, with exercise initiated 1 week prior to RT. Erectile function was quantified by intracavernosal pressure measurement 9 weeks after radiation. Plasma taken at sacrifice was evaluated for nitrite levels as a marker of NO. Penile shaft and cavernous nerve tissue were evaluated for evidence of oxidative stress and endothelial and neuronal functional/structural changes. RESULTS Irradiated animals had significantly worse erectile function than control and exercise groups (p<0.01). There was a trend for improved ICP/MAP ratio for Exercise+RT compared to RT animals with partial cohorts (p=0.35). More RT animals had ED than Exercise+RT (Table, p<0.001). No difference in resting nitrite levels was observed. Histologic correlates are pending. CONCLUSIONS Exercise may exhibit partial radioprotection for erectile function after prostate radiotherapy. C EX RT EX+RT p Mean ICP/MAP Ratio 0.737 0.753 0.444 0.534 0.001 Animals with ED 0% 0% 50% 38% 0.02 C control, EX exercise (6m/min × 1 hr, 5 days per week for 10 wks), RT 14 Gy single dose prostate radiotherapy. ICP/MAP intracavernosal pressure/mean arterial pressure © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e420 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mitchell Bassett Durham, NC More articles by this author Xiaochun Lu Durham, NC More articles by this author Hui Yan Durham, NC More articles by this author Yingchun Zhou Durham, NC More articles by this author Andrew Zodda Durham, NC More articles by this author Jason Allen Durham, NC More articles by this author Lee Jones Durham, NC More articles by this author Bridget Koontz Durham, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...