Abstract
We describe a multimodal approach for quantitative analysis of transcriptional and structural impacts imposed by structural variants in leukemic genomes. We uncover a new mechanism whereby loss of epigenetic barrier serves as the major determinant for the transcriptional output of enhancer hijacking, suggesting opportunities to reprogram gene regulation as epigenetic therapies. We describe a multimodal approach for quantitative analysis of transcriptional and structural impacts imposed by structural variants in leukemic genomes. We uncover a new mechanism whereby loss of epigenetic barrier serves as the major determinant for the transcriptional output of enhancer hijacking, suggesting opportunities to reprogram gene regulation as epigenetic therapies.
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