Abstract
Prostate cancer (PCa) is the most prevalent cancerin men and the second leading cancer death.Nearly 50% of patients have recurrence after definitive local therapy indicating an increased need for more effective therapies. We previously demonstrated (Hyer ML et al. Mol Ther 2(4):348|[ndash]|358, 2000) that adenovirus (AdGFPFasLTET) mediated overexpression of a GFPFasL fusion protein overcomes Fas resistance in DU145 cells induicng apoptosis. Bystander activity is also produced due to FasL presentation on apoptotic vesicles. However, some fraction of cancers, i.e DU145 xenografts, are resistant to bystander-mediated apoptosis (Hyer ML et al. Can Gene Ther10(4):330|[ndash]|339, 2003). We can promote sensitization to FasL bystander induced apoptosis by modification of ceramide metabolism.
Published Version
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