Abstract
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade multiple components of the extracellular matrix. The significant role of MMPs in tumor invasion, neoangiogenesis and metastasis presented it as ideal pharmacological targets for cancer therapy. The effects of ursolic acid (UA) on matrix metalloproteinase (MMP) gene expression, cell invasion and cell migration were investigated MDA MB- 231 cell line.
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