Abstract
1006. Effects of Modafinil on Emotional Processing in Patients with Remitted Depression
Highlights
Cognitive dysfunction in depression is an unmet treatment need
We showed that modafinil can improve episodic memory and spatial working memory in remitted depressed patients (Kaser et al 2016) In this report, we present the findings on the effects of modafinil on emotional processing in patients with remitted depression
Patients receiving modafinil showed a greater negative emotional bias (t(56) = 2.20, p=0.032) which appeared to be driven by longer reaction times to sad faces with neutral distracters compared to patients receiving placebo
Summary
Cognitive dysfunction in depression is an unmet treatment need. Cognitive deficits in depression tend to persist in remission, and are associated with poorer functional outcomes (McIntyre et al 2013). Patients with depression have cognitive deficits in cold cognition and hot cognition (emotion-laden). We showed that modafinil can improve episodic memory and spatial working memory in remitted depressed patients (Kaser et al 2016) In this report, we present the findings on the effects of modafinil on emotional processing in patients with remitted depression
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