Abstract
Since 1981 when first AIDS cases were identified in United States followed by Africa there has been growing understanding in the trajectory of HIV/AIDS across the world. The disease has caused unpredicted suffering, loss of life and disruption of family, social and economic abilities. Many therapies were introduced to treat AIDS. Those therapies have provided many insights in development of vaccine to decrease the pathogenecity and virulence of HIV. Here I will be discussing the strategies involved in the development of therapies for HIV. The treatments include Traditional vaccine designs, Novel Vaccine Designs and Antiretrovirals such as Protease inhibitors, Nucleotide Inhibitors, GP120 Inhibitors and modes of their action.
Highlights
Human immunodeficiency virus (HIV) (Human Immuno deficiency Virus) is a Lenti virus a member of Retro viral family which causes Acquired Immuno Deficiency Syndrome (AIDS) – which affects Immune system
HIV infection is characterized by a prolonged asymptomatic period of years to decades, which is followed by the fatal illness
Sub-Saharan Africa is disproportionally affected by HIV, comprising over two thirds (22.5 million) of the people living with HIV/AIDS worldwide and 76% of the AIDS deaths [11]
Summary
HIV (Human Immuno deficiency Virus) is a Lenti virus a member of Retro viral family which causes Acquired Immuno Deficiency Syndrome (AIDS) – which affects Immune system. HIV infection is characterized by a prolonged asymptomatic period of years to decades, which is followed by the fatal illness. Human immunodeficiency virus (HIV) infection has been associated with rhabdomyolysis [2]. The HIV isolates that infect humans and cause AIDS include a genetically diverse population of viruses [6]. Chronic human immunodeficiency virus (HIV) infection is characterized by defects in the immune system including depletion of CD4+ T-cells and impaired T-cell function. Lower Respiratory Tract Infections (LRTI) continues to be a major cause of morbidity and mortality in people living with HIV [10]
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