Abstract
Objective：Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms in the world. Death rate of HCC is the second rank of all cancer population in Taiwan, Genetic polymorphism has been reported as a factor to increase the risk of HCC. In the previously studies, stromal cell-derived factor-1 (SDF-1) and its receptor, a CXC chemokine Receptor 4（CXCR4）, play important roles in tumor cell proliferation, angiogenesis, and metastasis. The aim of this study was to estimate the relations of SDF-1 and CXCR4 gene variants on HCC risk and clinicopathological status. Methods and Materials：Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used to measure SDF-1 (rs1801157) and CXCR4 (rs2228014) gene polymorphisms in 311 healthy controls and 102 patients with HCC. Results：The individuals with at least one mutated A allele had 1.57 fold risk (95% CI: 1.00-2.47) to induce HCC and had 2.81 fold risk (95% CI: 1.04-7.58) to develop stage III or stage IV, after adjustment for other confounders. However, there was no significantly association between CXCR4 gene polymorphism and either HCC risk or pathological status. Additionally, both gene polymorphisms were not associated with the serum expression of liver-related clinical pathological markers. Conclution and suggestion： In conclusion, SDF-1-3’A gene polymorphism could be considered as a factor increasing the susceptibility and pathological development of HCC.
Published Version
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