Abstract
The discussion and purpose for the synthesis of this compound has been reported elsewhere [1].[...]
Highlights
To a solution of 4-benzyloxy-3-methoxybenzaldehyde (1.45 g, 6.0 mmol) in 50% THF/EtOH (100 mL) was added sodium hydroxide (0.5 g, 12.5 mmol, 2.1 eq) and pinacolone (2.0 g, 20 mmol, 3.3 eq) The resulting mixture was refluxed for 6 h
The mixture was concentrated in vacuo and the aqueous residue was extracted with dichloromethane (3 x 30 mL)
The organic fractions were combined, dried (MgSO4) and the solvent was evaporated in vacuo to give a brown oil
Summary
The discussion and purpose for the synthesis of this compound has been reported elsewhere [1]. To a solution of 4-benzyloxy-3-methoxybenzaldehyde (1.45 g, 6.0 mmol) in 50% THF/EtOH (100 mL) was added sodium hydroxide (0.5 g, 12.5 mmol, 2.1 eq) and pinacolone (2.0 g, 20 mmol, 3.3 eq) The resulting mixture was refluxed for 6 h (complete reaction by tlc).
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