1.1 Cell-Type–Specific Distributions of Cannabinoid Receptor 1 in Healthy and Illness States

Abstract

Alterations in the cannabinoid receptor 1 (CB1) are implicated in the development of psychopathologies. However, prior CB1 studies have shown discrepant results in postmortem brain samples obtained from patients with mental health disorders. These studies largely accounted for CB1 present on inhibitory boutons, yet it is known that CB1 participates in both depolarization-induced suppression of inhibition and excitation. Thus, examining cell type–specific CB1 alterations may offer clarity to prior findings and increase our insight into CB1’s influences on excitatory-inhibitory (E/I) balance in healthy and illness states.