082 Does tobacco smoke exposure influence allergie sensitization in children, according to maternal atopy?

Abstract

The negative impact of environmental tobacco smoke (ETS) on airway diseases in children is well known, however the effect of ETS on sensitization is still debated. The aim of the study was to evaluate whether if environmental tobacco exposure was associated with higher risk of sensitization, according to maternai atopy. Out of 9,000 children of 4 th and 5 th grade selected in six cities of France, 7,798 participated into the survey that included an epidemiological questionnaire (ISAAC-II), a medical examina-tion including skin prick test positivity to common allergens, skin examination for eczema, and run test to assess exercise-induced asthma (EIA). 25.2% had eczema, 12.9% rhinitis, 9.9% asthma and 25% had atopy. 21.7% had maternai atopy (MA). 21.6% of children were exposed to maternai ETS during pregnancy. In utero ETS was associated with SPT positivity to HDM (22.2% vs 15.4% ; p<0.001). There was no effect of paternal ETS on sensitization. Children with MA and exposed to in utero ETS, were at high risk to be sensitized to HDM (30%) compared with those with MA and non-exposed (19% : p : 0.001). Children with MA and exposed to maternai ETS during the first year of life, were at higher risk to be sensitized to cat (7.5% vs 3.4% ; p : 0.05), compared with children without maternai atopy. Smoking exposure seems to have a different effect on children sensitization, according maternai atopy and the time widow exposure.