0704 Association of high-risk obstructive sleep apnea with inflammatory markers in asymptomatic young and middle-aged adults in Miami Heart (MiHeart) Study at Baptist Health South Florida

Abstract

Abstract Introduction Obstructive Sleep Apnea (OSA) is associated with elevated inflammatory markers in those with cardiovascular disease (CVD). In contrast, there are limited data to support this association in asymptomatic individuals. The Miami Heart Study measured high sensitivity C-reactive protein (hs-CRP), Interleukin 6 (IL-6) and TNF- Alpha in a cohort of asymptomatic individuals from the general population. We hypothesized that there will be significant association of high OSA risk with inflammatory markers in Miami Heart Study cohort free of CVD. Methods We analyzed data for 2359 clinical CVD-free participants from the Miami Heart Study, age 40-65 years (May 2015-Sept 2018). High OSA risk included those with an OSA diagnosis and/or those with high risk using the Berlin questionnaire. Poisson regression analyses were utilized to examine the associations between high OSA risk (reference: low risk) and hs-CRP, IL-6 and TNF alpha levels (continuous), in univariate and multivariate models (adjusting for age, sex, race/ethnicity [model 2], and BMI, diabetes, hypertension, high cholesterol and smoking [model 3]). Results 800 (34%) participants were categorized as high OSA risk. Those with high OSA risk tended to be Hispanic, male, and with a higher CVD risk factor burden, especially obesity (64% vs 17%, p < 0.005) when compared to those with low OSA risk. Patients with high OSA risk had higher median values of hs-CRP (2.1 vs 1.0), IL-6 (2.0 vs 1.4), and TNF-alpha (1.2 vs 1.1) when compared to those with low OSA risk (all p < 0.001). When adjusting for age, sex, and race/ethnicity, the mean difference between patients with high and low OSA risk in hs-CRP was 1.86 (95% CI 1.69, 2.02), and 0.85 (95% CI 0.71, 0.99) in IL6. When further adjusting for CVD risk factors, these differences were attenuated, but statistically significant (hs-CRP [0.32, 95% CI 0.16, 0.48]; IL6 [0.37, 95% CI 0.21, 0.53]). In adjusted analyses, TNF-alpha was not statistically different between OSA risk populations. Conclusion Individuals at high risk for OSA had significant higher levels of hs-CRP and IL6, signaling to potential role of OSA in mediating the increased inflammatory markers in asymptomatic CVD risk free individuals. Support (If Any) Baptist Health South Florida