0505 : Pronostic value of biological markers in infective endocarditis

Abstract

Several biological markers are available to predict the evolution of septicemic patients in general. The aim of our study is to assess different biological markers in a population hospitalized for infectious endocarditis (IE) and their impact on in-hospital mortality. We analysed retrospectively 62 cases of IE recruited in cardiology department of the universal hospital of Casablanca between Juanary 2012 and October 2015. They were classified in two groups: Goupe with in-hospital death (GD), and groupe without in-hospital death (GND). The two groups was compared to clinical and biological parameters. The rate of mortality in our study is 9.6%. The average age is 37.41 years in GND and 40.18 years in GD (p= 0.53). The two groups also did not show significant differences in gender and the presumed portal of entry. Biologically, the average CRP level at admission was 52.52mg/l and 43.5 mg/l respectively in the GD and the GND (p<0.05). The average of creatinine clearance is 57.3ml/min and 59. ml/min respectiveley in the GD and the GND (p=0.67). The average leukocyte count is 40364 elements/mm 3 and 11212 elements/mm 3 respectively in the GD and the GND (p<0.05). The average of platelet rate is 306600 elements/mm 3 and 225470 elements/mm 3 respectively in the GD and GND (p<0.05). The hemoglobin level was 9.9g/dl and 10.6 g/dl respectively in GD and GND (p=0.42). The 24-hour proteinuria is 0.71 g/l and 0.21 g/l respectively in the GD and GND (p<0.05). In our study, high level of CRP and of leukocyte at admission, a thrombocythemia and an elevated proteinuria are associated with a high rate of in-hospital death. The author hereby declares no conflict of interest