Abstract

Atopic dermatitis (AD) and psoriasis are common inflammatory skin diseases. Both diseases show distinct clinical features and are driven by different immune signatures, but share some immune and barrier abnormalities. Chronic itch is a central feature of AD, but it is also the common reported symptom in psoriasis patients. Itch signal is transduced by specialized sensory neurons. However, little is known about the neuronal changes in AD and psoriasis. To address this issue, we first profiled the transcriptional changes in sensory neurons in mouse model of AD and psoriasis.

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