0383: The peculiarities of structural and functional state of myocardium and daily blood pressure profile in hypertensive patients with diabetes mellitus

Abstract

To establish the relationship between structural and functional parameters of the left ventricle (LV) and daily blood pressure (BP) profile in patients with arterial hypertension (AH) of II stage comorbid with type 2 diabetes mellitus (DM2). 68 patients (32 men and 36 women, mean age 49,6±5,2 years); 32 - with isolated hypertension (group 1), 36 - with hypertension and DM2 (group 2) were examined. We evaluated the data of transthoracic echocardiography and parameters of ambulatory blood pressure monitoring. Patients of the 1 st group had a significant increase of the LV posterior wall dimension (LVPWd) - 14% (p < 0,05) and left atrial size - 17%(p < 0,05). In patients of the 2 nd group a direct correlation between BP variability and LVPWd (r = 0,67; p <0.05) was revealed; as well as inverse correlation between daily average BP variability and a maximum velocity of early wave of mitral inflow (r =-0,51; p <0,05). In patients with hypertension comorbid with type 2 diabetes mellitus the following changes can be observed: the increase of BP variability, predomination of concentric left ventricular hypertrophy (65% of patients) over the eccentric one (29% patients) with the formation of diastolic dysfunction and impaired LV relaxation (51% of patients).