032 Sebaceous glands are actively and differentially involved in the pathogenesis of atopic dermatitis and psoriasis as revealed by spatial transcriptomics

Abstract

The primary function of sebaceous glands (SGs) is to produce the lipid rich sebum and thereby contribute to hair and skin lubrication. Recent findings however revealed that SGs may have immunoregulatory functions as well. We performed spatial transcriptomics (ST) on lesional and autologous non-lesional human skin samples of patients with psoriasis (PsO), atopic dermatitis (AD). Differentially expressed genes were identified followed by pathway enrichment analysis. Finally, a meta-analysis was done using RNAseq data from SZ95 human sebocytes treated with a combination of IL17 and TNFa to mimic the effect of a PsO-like microenvironment.