Abstract
Systemic lupus erythematosus (SLE) is a devastating systemic inflammatory disease, with prominent female bias. Recent literature suggests the OX40/OX40L costimulatory pathway may play an important role in development of SLE. GWAS have identified TNFSF4 (OX40L) as an SLE susceptibility locus. OX40L stimulation of T cells through the OX40 receptor has been shown to promote a T follicular helper (Tfh) phenotype, and Ox40l knockout has been demonstrated to ameliorate the SLE phenotype in transgenic and induced lupus mouse models.
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