Abstract
Copper accumulation in brain is common in many neurological diseases, such as Wilson’s disease. However, the effect of copper in specific brain regions remains unclear. 20 div of CuCl2 (500 μM) was injected into bilateral globus pallidus externus (GPe) in Rats. EEG/EMG and the behavior using real-time video were recorded. The sleep and movement-related parameters and the behaviors monitored by the video were analyzed and quantified by the software. For sleep, compared with the control rats, the wakefulness of copper-treated rats was significantly decreased in 24h, and the NREM was significantly increased in the light period and 24 h, while the REM did not change significantly. For the movement, compared with the control rats, the movement of copper-treated rats in the transformation period from NREM to wake was significantly increased in the light period, dark period and 24 h. The movement in the transformation period from REM to wakefulness was significantly increased in dark period. The movement of REM was not significantly changed. These data demonstrated that copper accumulation in GPe could cause movement deficits and sleep disorder, reminiscent of behavioral and sleep disorders as observed in Wilson’s disease and Parkinson’s disease. Our data suggested that GPe could be a crucial brain region involved in behavioral and sleep disorders in some neurological diseases such as Wilson’s disease and Parkinson’s disease. (Dr. Xifei Yang and Dr. Fei Qi have contributed equally to this work.) This work was supported by NSFC (the National Natural Science Foundation of China) (81673134, 81501213, 81571294), Guangdong Provincial Natural Science Foundation (2014A030313715, 2016A030313051), Guangdong Provincial Scheme of Science and Technology (To X.F.Y), and Shenzhen Special Fund Project on Strategic Emerging Industry Development(JCY20160428143433768, JCYJ20150529164656093, JCYJ20150529153646078).
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