Abstract
Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against desmogleins (Dsg) 1 and Dsg3 interfere with epidermal cell-cell adhesion, thereby causing blister formation and erosions of the skin and/or mucous membranes. Autoreactive Dsg-specific T cells play a central role in the PV pathogenesis. However, little is known about T cells in PV skin lesions and a detailed phenotypical and functional analysis is currently missing. Therefore, we aimed to comprehensively characterize T cells residing in lesional and perilesional skin of PV patients as well as matched peripheral blood compared to healthy controls.
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