Abstract
Adiponectin, a hormone secreted from adipocytes, is closely associated with psoriasis and suppresses psoriasiform inflammation. Recently, a small-sized transdermally deliverable 5-mer peptide (GLYYF; P5) was discovered as a potential adiponectin receptor 1 agonist. This study aims at confirming the reduction of adiponectin protein level in the human psoriasis skin and investigating whether functional adiponectin replenishment by topical P5 application improves psoriasiform skin inflammation. We examined the adiponectin protein expression in the skin of individuals with psoriasis and normal skin.
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