Abstract
Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous blistering disease. We previously showed that a genetic variant within the ST18 promoter promotes ST18 up-regulation in a p53/p63-dependent manner and is associated with a 6-fold increased risk to develop PV. ST18 was also found to be overexpressed in the skin of PV patients. In addition, it has been shown that desmoglein 3 (DSG3) down-regulation is associated with increased p53 expression and activity. Based on these data, using a combination of reporter assays, Western blotting, confocal immunofluorescence microscopy, we investigated the possibility that ST18, DSG3 and p53 may be jointly involved on the pathogenesis of PV.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
